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生物活性
Losartan 是一种血管紧张素II受体拮抗剂，与血管紧张素II AT1受体竞争性结合，IC50为20 nM。Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 mg/kg, i.p.) increases plasma renin levels 100-fold; plasma angiotensinogen levels decreases to 24% of control; and plasma aldosterone levels are unchanged.
化学数据
| 分子量 | 422.91 |
| 分子式 | C22H23ClN6O |
| CAS号 | 114798-26-4 |
| 纯度 | 100.00% |
| 溶解性（25°C） | DMSO: ≥ 80 mg/mL |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存 常温运输及临时存放 |
